What is it about?
The results presented here validates the use of dandelion herbal drug as potential anti-fibrotic agents and introduce it as a novel non-toxic alternative to conventional anti-fibrotic therapy available today.Dandelion prevents the progression of hepatic fibrosis induced by CCL4. The dandelion’s anti-fibrotic effects could be attributed to its ability to scavenge free radicals and to attenuate inflammatory cells activations.
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Why is it important?
In the present work, the hepatoprotective capacities of dandelion was shown to be more potent than our positive control, silymarin.in inhibition of liver fibrosis and inflammation. This could attribute to the differences in polyphenolic compounds classes and contents. Dandelion contains a wide array of phytochemicals include, sesquiterpene lactones, terpenoids, polysaccharides and phenolic compounds
Perspectives
Dandelion was effective in the prevention of CCL4-induced liver fibrosis in rats. The primary mechanism of this antifibrotic effect could be attributed to its antioxidant and anti-inflammatory properties.
Dr Alaaeldin A Hamza
National Organization for Drug Control and Research
Read the Original
This page is a summary of: Dandelion prevents liver fibrosis, inflammatory response, and oxidative stress in rats, The Journal of Basic and Applied Zoology, July 2020, Springer Science + Business Media,
DOI: 10.1186/s41936-020-00177-9.
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