four gene classes for translational control of mRNA

What is it about?

By looking for interactions with the main proteins regulating translational in yeast, we managed to group yeast genes into four major classes. These groups of genes interact differentially with the proteins involved in initiating translation, and possess different biophysical and functional properties.

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Why is it important?

All mRNAs are not translated in the the same way, with different translational control "levels" or "routes". We also observed one protein, CAF20, which is known to be involved in down-regulating translation interact with its own transcript - suggesting it auto-regulates its own translation and prevents the cell from completely shutting down translation.