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Curcumin is considered a chemopreventive molecule with anti-oxidant, anti-apoptotic and anti-inflammatory properties targeting both NRF2 and p53 and have anti-tumor activity. The oncosuppressor p53 plays a key role in cell growth and apoptosis in response to various stress signals while NRF2 is the main regulator of cellular antioxidant response. In this study authors evaluate the effect of a novel curcumin compound in several cancer cell lines carrying different endogenous p53 status indiciating the prosurvival role of curcumin-induced NRF2 expression in cancer cells even when cells underwent mutp53 downregulation and/or wtp53 activation.
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This page is a summary of: A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status, Journal of Experimental & Clinical Cancer Research, June 2020, Springer Science + Business Media,
DOI: 10.1186/s13046-020-01628-5.
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