What is it about?
Angiopoietin-like protein 3 (ANGPTL3) is a major lipoprotein regulator and shows positive correlation with high-density lipoprotein-cholesterol (HDL-c) in population studies and ANGPTL3 mutated subjects. However, no study has looked its correlation with HDL components nor with HDL function in patients with type 2 diabetes mellitus
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Why is it important?
ANGPTL3 is specifically correlated with HDL-c, apoA-I, SAA and HDL function in female non-diabetic participants. The decrease of ANGPTL3 level in female T2DM patients might contribute to its weak association to HDL components and function. ANGPTL3 could be considered as a novel therapeutic target for HDL metabolism for treating diabetes.
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This page is a summary of: Different relationship between ANGPTL3 and HDL components in female non-diabetic subjects and type-2 diabetic patients, Cardiovascular Diabetology, September 2016, Springer Science + Business Media,
DOI: 10.1186/s12933-016-0450-1.
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