What is it about?
DNA replication must be accurately controlled to avoid genetic instability and diseases such as cancer. We show here for the first time that the pyruvate kinase, a glycolytic enzyme that senses and fuels the cellular metabolism, is an important regulator of initiation and elongation of DNA replication.
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Why is it important?
Our findings suggest that genes and metabolite pools of central carbon metabolism form a new family of regulators of DNA replication and that disruption of this metabolic control of replication may be an additional root cause of cancer.
Perspectives
I hope that this paper will lead many scientists around the world to solve universal questions that have been unanswered for more than 50 years: how and why central metabolism controls DNA replication from bacteria to humans? This should shed new light on the role played by metabolic mutations and dysbiosis in carcinogenesis.
Dr Laurent Janniere
Genopole, CNRS, UEVE, Paris-Saclay
Read the Original
This page is a summary of: Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication, BMC Biology, April 2022, Springer Science + Business Media,
DOI: 10.1186/s12915-022-01278-3.
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