What is it about?
We searched for groups of distinct cognitive profiles in 35 relapsing-remitting MS outpatients and 32 healthy controls. All individuals participated in an automated assessment (CANTAB) and in a pencil and paper general neuropsychological evaluation.
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Why is it important?
Compared to the healthy control group, all MS outpatients had lower scores for RTI, RVP, paired associate learning, and delayed matching to sample. We suggest that the use of selected large-scale automated visuospatial tests from the CANTAB in combination with multivariate statistical analyses may reveal subtle and earlier changes in information processing speed and cognition. This may expand our ability to define the limits between normal and impaired cognition in patients with Multiple Sclerosis.
Perspectives
It is important to serach for moelcular profiles of each patient to understand subjacent mechanisms.
Dr Cristovam Wanderley Picanço Diniz
Universidade Federal do Para
Read the Original
This page is a summary of: The subtleties of cognitive decline in multiple sclerosis: an exploratory study using hierarchichal cluster analysis of CANTAB results, BMC Neurology, September 2018, Springer Science + Business Media,
DOI: 10.1186/s12883-018-1141-1.
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