Rotavirus vaccine effectiveness in a large cohort

What is it about?

Estimation of vaccine effectiveness is important. We assessed it in a large cohort of children vaccinated, when no herd immunity was expected. We also compared two cohorts, vaccinated and unvaccinated, that were very similar in relation to social and health characteristics.

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Why is it important?

Rotavirus vaccine effectiveness was calculated in a cohort of children in Spain, where the vaccine is not refunded. This poses a problem as the probability of being admitted in vaccinated (potentially higher social class) is lower in those that cannot afford to be vaccinated. Therefore the control cohort was children that got prevenarTM (also not refunded by the goverment). So both cohorts were similar. The study showed a high vaccine effectiveness. No herd effect detected.