What is it about?
Sickle cell disease (CSD) is an inherited disease with abnormal haemoglobin in which the small blood vessels are occluded by the abnormally-shaped red blood cells. This vaso-occlusion can be caused by different factors. We measured the coagulability status of the blood in a group of children with SCD. Also, we assessed the effect of treatment with either omega-3 (n-3) fatty acids or hydroxyurea (HU) on the coagulation profile.
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Why is it important?
This study provides an evidence that Sudanese children with sickle cell disease have an abnormal coagulating profile which characterized by prolonged PT and aPTT compared to heathy controls. These two parameters were significantly reduced by treatment with either HU or omega-3 fatty acids. With the exception of the D-dimer, treatment with neither omega-3 fatty acids nor HU resulted in a significant change in markers of coagulation compared to the untreated group.
Perspectives
I hope this article makes doctors thick of the coagulation status when treating children with SCD. It was a great pleasure to collaborate with eminent co-authors in this research. I hope you enjoy reading this article and you find it thought-provoking.
Professor Nazik Elmalaika Obaid Seid Ahmed Husain
Faculty of Medicine and Health Sceinces, Omdurman Islamic University
Read the Original
This page is a summary of: Coagulation profile of Sudanese children with homozygous sickle cell disease and the effect of treatment with omega-3 fatty acid on the coagulation parameters, BMC Hematology, November 2017, Springer Science + Business Media,
DOI: 10.1186/s12878-017-0089-5.
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