What is it about?
Human sweat contains DNA which can be sequenced, this DNA is associated with sweat particles and sweat extracellular vesicles. We found that mitochondrial DNA is highly represented and that some region of each human chromosomes are also very abundant while most are absent. We could also identify bacterial DNA and viral DNA, most of it belonging to skin associated microorganisms. We also identified small RNA: miRNA, tRNA, rRNA and other noncoding RNA associated with extracellular vesicles. Fragment of processed mRNA were also identified, showing that human exercise sweat is a potential source of nucleic acid biomarkers.
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Why is it important?
This report the NGS data obtained from RNA and DNA extracted from the upper body sweat of several individuals. We show and characterize nucleic acids from sweat extracellular vesicles collected during exercise.
Perspectives
This work shows that it is possible to obtain individual genomic data from sweat particles. It shows also that diverse collection of small RNA and mRNA can be identified from Extracellular Vesicles enriched sweat. This shows that skin surface and sweat could serve for real-time detection of specific biomarkers at least for sport practice.
Dr Geneviève Bart
university of Oulu
Read the Original
This page is a summary of: Characterization of nucleic acids from extracellular vesicle-enriched human sweat, BMC Genomics, June 2021, Springer Science + Business Media,
DOI: 10.1186/s12864-021-07733-9.
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