What is it about?
Genes and genomes duplicate during evolution, followed by functional diversification. This study show how how USP4, USP15 and USP11 evolved and functionally diversified. Phylogenetic trees were constructed and corroborated by analysis of gene synteny, based on the rationale that recently diverged paralogous genes will share more flanking genes in the same order than those having diverged for a long time.
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Why is it important?
The order of gene duplication are essential for inferring subsequent subfunctionalization and neofunctionalization. "He who sees things from the very beginning has the most advantageous view of them".
Perspectives
This paper provides a standard framework for studying paralogous genes.
Prof. Xuhua Xia
University of Ottawa
Read the Original
This page is a summary of: Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11, BMC Evolutionary Biology, October 2015, Springer Science + Business Media,
DOI: 10.1186/s12862-015-0511-1.
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