Brain perfusion SPECT and magnetic resonance imaging

What is it about?

To compare the diagnostic value of the perfusion pattern of SPECT and atrophy pattern of MRI for neurodegenerative dementia and its early detection we studied patients with different types of dementia.107 patients underwent MRI and SPECT using HMPAO at the Department of Radiology and Nuclear Medicine of AHEPA University Hospital. Our patients based on clinical diagnosis were categorized into 3 groups: a) Neurodegenerative dementia (ND) consisted of 61 patients (mean age71±9) with Alzheimer's disease (AD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and mixed dementia, b) Vascular cognitive impairment VCI consisted 27 patients (mean age 70±7), and c) Normal group included 19 persons (mean age 64±7). MR images and SPECT images were visually evaluated and grouped also into 3 categories: Neurodegenerative (ND) pattern, vascular impairment (VI) pattern and normal pattern.

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Why is it important?

The sensitivity, specificity, positive and negative predictive value for MR imaging were72%, 98%, 97% and 77% and for SPECT 98%, 93%, 95% and 97% respectively. The sensitivity and specificity of visually evaluating MR images in the cases with mild stages of the disease was 47% and 95%and for SPECT 93% and 95% respectively. MRI helped us in detecting microangiopathies in our patients by showing white matter hyperintensities which can not be detected by SPECT.

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