What is it about?
ChIP-seq is a method widely used for identifying where transcription factors (TFs) bind to the genome. If you have two different ChIP-seq experiments for the same TF, you can use CentriMo in differential mode to compare them. This can for example test whether a specific motif is really specific to a given set of binding sites.
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Why is it important?
Identifying where TFs bind is important for understanding genomic regulation. TFs regulate transcription, the first step in creating proteins.
Perspectives
I have found differential mode and other added features described here like checking for enrichment anywhere in a sequence not just central enrichment (what CentriMo originally does) useful in a variety of scenarios.
Philip Machanick
Rhodes University
Read the Original
This page is a summary of: Differential motif enrichment analysis of paired ChIP-seq experiments, BMC Genomics, January 2014, Springer Science + Business Media,
DOI: 10.1186/1471-2164-15-752.
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