What is it about?
Some class II alleles and one haplotype is associated with presenting autoantibodies in hypersensitivity pneumonitis patients. Interestingly, these alleles have been described as part of the 8.1 ancestral haplotype. Also, associated with autoimmune diseases.
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Why is it important?
These alleles and haplotype have been described previously associated with several autoimmune disorders.
Perspectives
Identify genetic sequences characterizing this particular phenotype could contribute to its understanding.
Dr. Ramcés Falfán-Valencia
Instituto Nacional de Enfermedades Respiratorias
Read the Original
This page is a summary of: A major genetic determinant of autoimmune diseases is associated with the presence of autoantibodies in hypersensitivity pneumonitis, European Respiratory Journal, May 2020, European Respiratory Society (ERS),
DOI: 10.1183/13993003.01380-2019.
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