Model systems of genetically modified platelets

What is it about?

This article provides an overview of in vivo models to produce and test genetically modified human platelets. It describes how genetically modified human platelets are produced in zebrafish, knock out/in mice and humanized mice, along with their strengths and weaknesses, and highlights the most important findings obtained with each model. The article ends with a look ahead towards emerging techniques such as TALENs.

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Why is it important?

This article provides a good overview and comparison of the available animal models. It is a good starting point for readers who want to deepen their knowledge on the subject and select a suitable model for their own research project.