What is it about?
Weight gain induced Insulin Resistance leads to compensatory Insulin hypersecretion. So obese Type 2 Diabetes patients have increased fasting insulin levels. But non-obese Indians suffering from Type 2 Diabetes have been reported to have low levels of insulin. We tested whether the phenomenon of insulin hypersecretion holds true for non-obese Indians.
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Why is it important?
Our findings provides the possibility that Type 2 Diabetes in non-obese people has a different pathology than the classically known Type 2 Diabetes. This is important from the aspect of screening and even therapy for non-obese patients.
Perspectives
Our report supports the possibility of Type 2 Diabetes to have a different natural history in non-obese Indians. This possibility calls for a different screening criteria in non-obese Indians and also asks for further research towards developing new therapy options for this group.
Dr Jit Sarkar
CSIR-Indian Institute of Chemical Biology
Read the Original
This page is a summary of: Impaired compensatory hyperinsulinemia among nonobese type 2 diabetes patients: a cross-sectional study, Therapeutic Advances in Endocrinology and Metabolism, January 2019, SAGE Publications,
DOI: 10.1177/2042018819889024.
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