Microphysiological systems for developmental toxicology

What is it about?

This ‘commentary’ summarizes research needs and opportunities for organ-on-a-chip models for developmental and reproductive toxicity testing. Emerging concepts can be taken forward to a virtual tissue modeling framework for assessing chemical (and non-chemical) stressors on human development.

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Why is it important?

These models will advance children’s health research, both basic and translational and new ways to evaluate complex embryological and reproductive impacts of drug and chemical exposures to inform safety assessments.