What is it about?
Continuous studies have shown that insula may be an important target of AD, but neuropathological alterations have not been described extensively. In the present study, we attempted to describe the morphometric and morphological changes of the spines of Reil insula in AD in comparison with normal aging using a silver impregnation technique.
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Why is it important?
We described the morphological alterations of dendritic spines in AD. The spines were classified into 3 types: long neck,short stubby, and other types; Tremendous loss of spines was observed in brains of patients who suffered from AD in correlation to normal controls.
Perspectives
The alteration of dendritic spines in the neuronal networks of the insula in AD may explain the visceral dysfunction in advanced cases of the disease. The correlation between visceral complains and synaptic pathology in insula may contribute in shaping the psychosomatic profile of AD.
Professor Stavros J Baloyannis or Balogiannis or Balojannis or Baloyiannis or Mpalogiannis
Aristotle University of Thessaloniki
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This page is a summary of: Spinal Alterations of Reil Insula in Alzheimer’s Disease, American Journal of Alzheimer s Disease & Other Dementias®, April 2017, SAGE Publications,
DOI: 10.1177/1533317517703476.
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