Evidence-based practice in times of drug shortage

What is it about?

We explain how to deduce therapeutic alternatives based on pharmacokinetic and pharmacodynamic principles in the absence of direct clinical evidence.

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Why is it important?

The lack of direct clinical evidence does not mean that a recommendation cannot be made when addressing essential drug shortages. The conscientious, explicit, and judicious use of the next best external evidence can still support high-quality decision-making.