What is it about?
This is an example of a malignancy of B lymphocytes, causing enlargment of lymph nodes in an elderly gentleman, but also involving blood vessels, a rather unusual finding.
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Why is it important?
This lymphoma had a peculiar phenotype, in that it expressed CD5, a marker usually seen in T cells rather than B cells, and caused cutaneous lesions, something more typical of another B cell lymphoma, which however involves only the lumina of blood vessels.
Perspectives
A skin biopsy can disclose a potentially fatal neoplasia of lymphocytes, but there are pitfalls that need to be taken into account...
Carlos Santonja
Hospital Universitario Fundación Jiménez Díaz
Read the Original
This page is a summary of: De Novo CD5-Positive Diffuse Large B-Cell Lymphoma, International Journal of Surgical Pathology, July 2016, SAGE Publications,
DOI: 10.1177/1066896916660196.
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