What is it about?

The paper give advice on choosing sample sizes for groups of n of 1 trials. Different possible tasks are considered, since the necessary sample size depends on whether one merely wishes to establish whether a given treatment has any effect, or whether one wishes to predict the effect in future patients.

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Why is it important?

It is important because it links planning to analysis and analysis to purpose. The fact that n-of-1 trials might have different purposes has not always been appreciated.

Perspectives

This is a sister publication to the recent article with Artur Araujo and Stephen Julious on analysis of n-of-1 trials. Readers may wish to consult that article, which is an open access paper: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167167

Professor Stephen J Senn
Consultant Statistician

Read the Original

This page is a summary of: Sample size considerations for n-of-1 trials, Statistical Methods in Medical Research, September 2017, SAGE Publications,
DOI: 10.1177/0962280217726801.
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