What is it about?
The paper give advice on choosing sample sizes for groups of n of 1 trials. Different possible tasks are considered, since the necessary sample size depends on whether one merely wishes to establish whether a given treatment has any effect, or whether one wishes to predict the effect in future patients.
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Why is it important?
It is important because it links planning to analysis and analysis to purpose. The fact that n-of-1 trials might have different purposes has not always been appreciated.
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Read the Original
This page is a summary of: Sample size considerations for n-of-1 trials, Statistical Methods in Medical Research, September 2017, SAGE Publications,
DOI: 10.1177/0962280217726801.
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Resources
R, GenStat and SAS Code for Sample Size Considerations in N-of-1 trials
Code is provided for three statistical packages to enable users to calculate sample sizes for n-of-1 trials
Understanding Variation in Sets of N-of-1 Trials
This paper describe different analyses for different purposes to which n-of-1 trials might be put.
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