What is it about?
Ionizing radiation is a widely used therapy for solid tumors. However, high-dose ionizing radiation causes apoptosis, transforms normal cells into tumor cells, and impairs immune functions, leading to the defects in the removal of damaged or tumor cells. In contrast, low-dose radiation has been reported to exert various beneficial effects in cells.
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Why is it important?
Low-dose γ ray significantly inhibited DMH-induced colon carcinogenesis in rats by modulating CK20, MDR1, and β-catenin expression but not survivin expression.
Perspectives
γ ray at low dose significantly inhibited DMH-induced colon carcinogenesis in rats by modulating β-catenin, MDR1 and cytokeratin 20 expression but not survivin expression. Overall, the present data indicate that low dose of γ radiation holds great promise in the field of colon cancer radiotherapy.
Professor Ahmed E Abdel Moneim
Helwan University
Read the Original
This page is a summary of: Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression, Human & Experimental Toxicology, April 2015, SAGE Publications,
DOI: 10.1177/0960327115584687.
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