What is it about?
Epidemiological reports have indicated a correlation between the increasing bisphenol A (BPA) levels in the environment and the incidence of male infertility. In this study, the protective effects of melatonin on BPA induced oxidative stress and apoptosis were investigated in the rat testes and epididymal sperm. The concurrent administration of melatonin decreased oxidative stress by modulating the levels of glutathione, superoxide dismutase, and catalase as well as the malondialdehyde and hydrogen peroxide concentrations in the testes and sperm. Melatonin sustained Bcl-2 expression and controlled apoptosis. Furthermore, melatonin maintained the testosterone levels, ameliorated histopathological changes, increased the percentages of seminal haploid germ cells, and protected sperm chromatin condensation process, indicating appropriate spermatogenesis with production of functional sperm. In conclusion, melatonin protected against BPA-induced apoptosis by controlling Bcl-2 expression and ameliorating oxidative stress in the testes and sperm. In conclusion, melatonin is a promising pharmacological agent for preventing the potential reproductive toxicity of BPA following occupational or environmental exposures.
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Why is it important?
Epidemiological reports have indicated a correlation between the increasing bisphenol A (BPA) levels in the environment and the incidence of male infertility. In this study, the protective effects of melatonin on BPA induced oxidative stress and apoptosis were investigated in the rat testes and epididymal sperm.
Perspectives
Melatonin protected the testis and epididymal sperm quality against BPA-induced oxidative damage and apoptosis. The protective mechanism of Melatonin involved integration between its ability to control cellular redox balance and its antiapoptotic action. It is anticipated that MLT supplementation might not only protect male fertility but also assist normal fertilization, and it prevents the transfer of defective paternal DNA to the progeny.
Mohamed Amr Ahmed El-Missiry
Mansoura University
Read the Original
This page is a summary of: Melatonin controlled apoptosis and protected the testes and sperm quality against bisphenol A-induced oxidative toxicity, Toxicology and Industrial Health, July 2016, SAGE Publications,
DOI: 10.1177/0748233714561286.
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