What is it about?
anti-migraine drugs blocking the receptor for the neurtransmitter CGRP have shown some toxic effect when tested. Studying the effect of CGRP on neuron in culture indicated that it might have strong protective effects. We tested it experimentally
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Why is it important?
When developing treatment against migraine it is important not promote drugs that may have toxic effect for the brain. Here we show that preventing the binding of CGRP with its receptor has detrimental effect on trigeminal neurons and how.
Perspectives
Choosing the right target for drug development is very important, this study highlights the positive effect of CGRP on brain function which cannot be ignored.
Dr Geneviève Bart
university of Oulu
Read the Original
This page is a summary of: Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling, Cephalalgia, November 2016, SAGE Publications,
DOI: 10.1177/0333102416681588.
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