What is it about?
Limb pain can be a migrainous symptom. We decribe four generations of a family with limb pain associated to migraine headaches in children and adults, with a dominant pattern of inheritance, possibly autosomal.
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Why is it important?
This is the first demonstration that limb pain associated with migraine headaches occurs not only sporadically in adults but that can also be inherited and occur in children. It also proves that limb pain in children, often diagnosed as "growing pains" behaves similarly to other periodic síndromes associated to migraine in children, like recurrent abdominal pain. The association of limb pain and migraine is not well known, the symptoms are benign and treatable as migraine headaches, acutely or prophylactically.
Perspectives
Limb pain in migraine and cluster headache was described in adults in 1988 (JNNP; 51: 1022-1031), and subsequently a number of other cases have been added in the literature. Proof that the same association could be seen seen in children was lacking. The finding that it can be inherited will allow further investigation of the molecular genetics mechanisms that underlie this phenotype.
Professor Roberto J Guiloff
Imperial College London
Read the Original
This page is a summary of: Familial limb pain and migraine: 8-year follow-up of four generations, Cephalalgia, July 2016, SAGE Publications,
DOI: 10.1177/0333102415620906.
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