Oxidative Stress and Sperm Quality: Initial Vietnamese Study

What is it about?

This study aimed to determine the relationship between oxidative stress (OS) and semen analysis among infertile men. The oxidation-reduction potential (ORP) was used as a measure of OS. The results showed that men with OS had a higher DNA fragmentation index (DFI) and lower sperm quality. The optimal ORP threshold for determining sperm quality was found to be 0.77 mV/10^6 sperm/mL. The study concluded that OS adversely affects sperm quality and suggested that maintaining a healthy lifestyle and regular exercise may improve sperm quality. The study also found a correlation between ORP and semen analysis results.

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Why is it important?

This study is important because it highlights the relationship between oxidative stress (OS) and semen analysis among men from infertile couples. Understanding the impact of OS on sperm quality and fertility is crucial for identifying potential causes of male infertility, improving diagnostic methods, and developing effective treatments. Key Takeaways: 1. OS has a negative impact on sperm quality, as indicated by lower sperm concentration, total sperm count, sperm motility, normal morphology, and higher DNA fragmentation index (DFI). 2. The optimal oxidation-reduction potential (ORP) threshold for determining sperm quality is 0.77 mV/10^6 sperm/mL, with a sensitivity of 50.4%, specificity of 93.5%, positive predictive value of 52.9%, and negative predictive value of 32.3%. 3. The MiOXSYS system is a user-friendly, cost-effective, and accurate method for measuring ORP in human sperm, which can be used to assess sperm quality in infertile patients.