What is it about?
A within-patent study comparing optimal isomers carried out in at Kalamazoo in 1905 is described and a brief biography of its prime mover, Arthur Cushny is provided.
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Why is it important?
The trial, although it can be criticised a modern perspective, was innovative and important in its use of control, alternation and repeated treatment and measurement. Ethical issues were also not neglected by the authors. the data they presented were later (1908) used by Student to illustrate his t-test. Student's paper is regarded as an important milestone on the road of modern statistical development.
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This page is a summary of: Cushny and Peebles, optical isomers and the birth of modern statistics, Journal of the Royal Society of Medicine, December 2017, SAGE Publications,
DOI: 10.1177/0141076817743188.
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