What is it about?
A series of 6-alkoxy-3-aryl-[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazine derivatives have been synthesized and evaluated for their antitumor activities. These compounds exhibited potent antiproliferative activities against A549, Bewo and MCF-7 cells. Molecular docking was further performed to study the inhibitor-c-Met kinase interactions, and the results show that compound 5j was potently bound to the c-Met kinase with two hydrogen bonds and one π---π interaction. Based on the preliminary results, it is deduced that compound 5j with potent inhibitory activity may be a potential anticancer agent.
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Why is it important?
A series of 6-alkoxy-3-aryl-[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazine derivatives have been synthesized and evaluated for their antitumor activities. These compounds exhibited potent antiproliferative activities against A549, Bewo and MCF-7 cells. Molecular docking was further performed to study the inhibitor-c-Met kinase interactions, and the results show that compound 5j was potently bound to the c-Met kinase with two hydrogen bonds and one π---π interaction. Based on the preliminary results, it is deduced that compound 5j with potent inhibitory activity may be a potential anticancer agent.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research.
Feng Xu
Taizhou Vocational and Technical College
Read the Original
This page is a summary of: Synthesis and biological evaluation of novel 6-alkoxy-3-aryl-[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazines, Journal of Chemical Research, July 2019, SAGE Publications,
DOI: 10.1177/1747519819861865.
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