What is it about?
This is a study of psychiatric co-morbidities in the Fragile X-associated tremor-ataxia syndrome (FXTAS), an illness specific to the premutation carriers of Fragile X. These patients have characteristic neuropsychiatric findings that progress over time.
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Why is it important?
FXTAS patients often manifest a frontal-subcortical dementia plus other psychiatric co-morbidity. FXTAS should be considered as a diagnosis in dementia with a movement disorder in patients with other Fragile X illnesses in their pedigree.
Perspectives
This is one of the first studies of early and middle stage FXTAS, showing that psychiatric co-morbidity is common, even in those premutation carriers yet to develop a full dementia syndrome.
James Bourgeois
University of California, Davis Medical Center
Read the Original
This page is a summary of: Psychiatric Manifestations in Early to Middle Stages of Fragile X-Associated Tremor-Ataxia Syndrome (FXTAS), Journal of Neuropsychiatry, August 2024, American Psychiatric Association,
DOI: 10.1176/appi.neuropsych.20230215.
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