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In this priority data letter, we comment on the FOUR-D trial by Blumberger et al. and discuss further on the rationale of using more intensive TBS protocol in treating late-life treatment resistant depression (TRD) bringing some preliminary evidence of the potential benefit of such protocol.

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This page is a summary of: An Avenue for Optimization of Theta Burst Stimulation Protocols? Comments on the FOUR-D Randomized Noninferiority Clinical Trial, American Journal of Psychiatry, November 2023, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20230236.
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