What is it about?
This conceptual replication study aimed to test whether distinct functional MRI patterns of threat and reward reactivity are associated with post-traumatic symptoms. Identified clusters were not identical to the previously identified brain-based biotypes and were not associated with prospective symptoms of posttraumatic psychopathology.
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Why is it important?
Because we show that even small changes in sample characteristics or experimental tasks can greatly impact the replicability of neuroimaging-based biotypes and their link to prospective clinical symptoms. Caution is warranted before treatment implications can be fully realized. Replication attempts are the key to moving forward and discovering stable & generalizable brain-based biotypes of psychiatric disorders!
Perspectives
While replication studies are crucial, they are rare, because they are often undervalued, can be difficult to publish, and offer few direct incentives for researchers. I wish to thank Dr. Jennifer Stevens and the AURORA team for their commendable collaboration, which was essential for this work to happen.
Dr. Ziv Ben-Zion
Yale University
Read the Original
This page is a summary of: Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma, American Journal of Psychiatry, January 2023, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20220271.
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