What is it about?

This article provides clinical pearls and insights into the different properties of long acting injectable antipsychotic medications to enable a provider to switch between the medications. This article reviews both package insert recommendations and those of clinical practice.

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Why is it important?

These recommendations are important as there is very little guidance on how to switch between long acting injectable antipsychotic medications. Understanding the pharmacokinetic properties of the various formulations is essential to understanding how to switch between the medications.

Perspectives

At times, providers or patients may select to change between long acting injectable antipsychotic medications. There is very little guidance available in the literature or package insert labeling as to how to effectively transition between the medications. Clinical pearls and pharmacokinetic information is provided to assist the provider in making an effective transition.

Megan Ehret
University of Maryland Baltimore

Read the Original

This page is a summary of: Switching Between Long-Acting Injectable Antipsychotic Medications, FOCUS The Journal of Lifelong Learning in Psychiatry, October 2025, American Psychiatric Association,
DOI: 10.1176/appi.focus.20250021.
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