What is it about?
FXR activated by bile acids represses apoA expression and thus circulating Lp(a) by a direct repression on the promoter activity, this is the first of 2 articles defining how FXR directly and non directly via FGF19 represses apoA
Featured Image
Why is it important?
FXR agonists could lower Lp(a) and thus improve cardio vascular risks
Read the Original
This page is a summary of: Farnesoid X receptor represses hepatic human APOA gene expression, Journal of Clinical Investigation, September 2011, American Society for Clinical Investigation,
DOI: 10.1172/jci45277.
You can read the full text:
Contributors
The following have contributed to this page
