What is it about?
Using cell lines derived from different anatomical sites they show that those from lymph node metastases express ligands for DNAM-1 (DNAM-1L), mainly CD155, and for NCRs, but low levels of ligands for NKG2D (NKG2DL).
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Why is it important?
Simultaneous engagement of several activating receptors contributes to efficient NK cell-mediated lysis of melanoma cells. Moreover, DNAM-1 and NKG2D crosslinking may also contribute to T cell activation.
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This page is a summary of: Multiple activating receptor-ligand interactions control NK cell recognition and killing of melanoma cells, Journal of Clinical Investigation, June 2009, American Society for Clinical Investigation,
DOI: 10.1172/jci36022l1.
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