What is it about?
FXR represses apoA1 expression in hepatocytes in humans and in humanized mouse model thus lowering HDL and increasing cardio vascular risk
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Why is it important?
FXR antagonists could then alleviate cardio vascular risks by inducing apoA1 expression and cholesterol excretion into the bile
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This page is a summary of: Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element, Journal of Clinical Investigation, April 2002, American Society for Clinical Investigation,
DOI: 10.1172/jci0214505.
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