What is it about?
Some tear proteins are disturbed when patients instill glaucoma eyedrops chronically. This include the rise of inflammation regulators like S100A8 proteins, and also scafolding protein 14-3-3 isoforms.
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Why is it important?
Increased inflammation may predispose to fibrosis: leading to poor outcomes in glaucoma surgery later. Increased ocular surface inflammation leads to symptoms of dry eye and likely poor compliance to glaucoma medications, leading to progression of glaucoma and loss of eyesight.
Perspectives
14-3-3 protein is important for recognition of ocular surface disease in glaucoma patients.
Prof Louis Tong
National University of Singapore
Read the Original
This page is a summary of: Proteomic Profiling of Inflammatory Signaling Molecules in the Tears of Patients on Chronic Glaucoma Medication, Investigative Ophthalmology & Visual Science, September 2011, Association for Research in Vision and Ophthalmology (ARVO),
DOI: 10.1167/iovs.10-6532.
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