What is it about?
Retinal ischemia may provoke blindness. There is no effective treatment against retinal ischemic damage. We investigated whether brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina from ischemia-reperfusion damage. Postconditioning initiated between 5 and 60 minutes after reperfusion protected against ischemic injury. Retinal protection depended on the number of ischemia-reperfusion cycles. Seven ischemia-reperfusion cycles applied 5 minutes after reperfusion afforded significant functional protection in eyes exposed to ischemia-reperfusion injury.
Featured Image
Why is it important?
These results indicate that postconditioning significantly protected retinal function and histology from ischemia-reperfusion injury through a mechanism that involved de novo synthesis of protein.
Perspectives
It will help to design new therapies to treat retinal ischemic damage.
PhD Melina Paula Bordone
Departamento de Fisiología y Biología Molecular y Celular (FBMC), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires
Read the Original
This page is a summary of: Retinal Neuroprotection against Ischemia-Reperfusion Damage Induced by Postconditioning, Investigative Ophthalmology & Visual Science, August 2009, Association for Research in Vision and Ophthalmology (ARVO),
DOI: 10.1167/iovs.08-3344.
You can read the full text:
Contributors
The following have contributed to this page
