Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Asthmatics

What is it about?

The increased production of mucus is a major issue in asthma. We show that Notch3, a member of an essential developmental protein family, is increased in the lungs of people with asthma. Blocking Notch3 activation reduces production and release of the mucus protein MUC5AC in airway cells from asthma donors.

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