Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis

What is it about?

Pulmonary GMCSF regulates alveolar macrophage survival, proliferation, maturation, and expansion. We show for the first time that chronically increased expression of pulmonary GM-CSF in mice results in a lung phenotype strikingly similar to desquamative interstitial pneumonitis, an observation with pathogenic implications for the human disease.

Featured Image