What is it about?
ILC2 cells are a recently described innate-cell subset which can drive a type 2 cytokine response and are therefore of interest in human asthma. These cells were discovered in mice but have been hard to identify in humans because they are such rare events. There is a concern that some reports of ILC2 cells in human asthma may be affected by inaccurate gating strategies which could have non-ILC2 cells counted as ILC2s
Featured Image
Why is it important?
ILC2 cells have attracted a lot of research interest, but it is vital that conclusions are based on high quality data. The potential error we highlight here is of interest to all human ILC2 researchers.
Perspectives
This paper points to a key issue, and potential pitfall, in ILC2 research.
Timothy SC Hinks
University of Oxford
Read the Original
This page is a summary of: Cytometric Gating Stringency Impacts Studies of Type 2 Innate Lymphoid Cells in Asthma, American Journal of Respiratory Cell and Molecular Biology, December 2017, American Thoracic Society,
DOI: 10.1165/rcmb.2017-0201le.
You can read the full text:
Contributors
The following have contributed to this page
