Characterization of Physico-Chemical and Spectroscopic Properties of Biofield Energy Treated 4-Bromoacetophenone

What is it about?

4-Bromoacetophenone is an acetophenone derivative known for its usefulness in organic coupling reactions and various biological applications. The aim of the study was to evaluate the impact of biofield energy treatment on 4-bromoacetophenone using various analytical methods. The material is divided into two groups for this study i.e. control and treated. The control group remained as untreated and the treated group was subjected to Mr. Trivedi’s biofield energy treatment. Then, both the samples were characterized using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), gas chromatography-mass spectrometry (GC-MS), and UV-visible spectrometry (UV-vis). The XRD study revealed that the crystallite size of treated 4-bromoacetophenone was decreased significantly to 16.69% with decreased intensity as compared to the control. The thermal studies revealed that the slight change was observed in the melting point and latent heat of fusion (∆H) of biofield energy treated sample as compared to the control. Maximum degradation temperature (Tmax) of treated 4-bromoacetophenone was decreased by 7.26% as compared to the control (169.89°C→157.54°C). The FT-IR spectra showed that the C=O stretching frequency at 1670 cm-1 was shifted to higher frequency region (1672 in T1 and 1685 cm-1 in T2, in two treated samples for FT-IR) after biofield energy treatment. Moreover, the GC-MS data revealed that the isotopic abundance ratio of either 13C/12C or 2H/1H (PM+1)/PM was decreased up to 9.12% in T2 sample whereas increased slightly up to 3.83% in T3 sample. However, the isotopic abundance ratio of either 81Br/79Br or 18O/16O (PM+2)/PM of treated 4-bromoacetophenone was decreased from 0.10% to 1.62% (where PM-primary mass of the molecule, (PM+1) and (PM+2) are isotopic mass of the molecule). The UV spectra showed the similar electronic behavior like absorption maximum in control and treated samples. Overall, the experimental results suggest that Mr. Trivedi’s biofield energy treatment has significant effect on the physical, thermal, and spectral properties of 4-bromoacetophenone.

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Why is it important?

4-Bromoacetophenone is basically a natural product and found in the environment as degradation products of industrial chemicals. It is used as a basic starting material in most of the metal catalyzed coupling reactions due to the presence of both electron-rich and electron-withdrawing functionalities within the same molecule [1]. In biological systems, halogen bonding has its importance due to their high directionality and specificity. Therefore, they can be used effectively in drug design to direct the binding of ligands to the target sites [2]. The bromoacetophenone derivatives upon excitation with ultraviolet radiation can generate phenyl radicals. The utility of haloarenes were studied by Paul et al., as radical progenitors for DNA cleavage. It is reported that haloarenes are readily available compounds upon UV excitation and halo acetophenones are effective DNA cleaving agents [3, 4]. 4-Bromoacetophenone has been used as basic starting material in coupling reactions such as Heck coupling, Suzuki coupling, and Stille reactions [5]. Furthermore, guaiacyl, syringyl, and p-hydroxyphenyl-type bromoacetophenone derivatives were synthesized as the starting materials for β-O-4 type artificial lignin polymers [6]. Apart from that, the acetophenones were screened for activity against positive phototaxis of Chlamydomonas cells, a process that requires coordinated flagellar motility. Several acetophenones including 3, 4-dimethylacetophenone, and 4-ethylacetophenone showed inhibitory effects on phototaxis in Chlamydomonas, in a concentration-dependent manner, indicating that these compounds nonspecifically interfere with phototaxis by disrupting overall cell viability [7]. Due to their wide range of applications in biology and synthetic organic chemistry, the objective of the current study was to evaluate the impact of biofield energy treatment on the physical and chemical properties of 4-bromoacetophenone. The biofield is defined as the complex dynamic electromagnetic (EM) field. The field resulting from the EM fields contributed by each individual oscillator or electrically charged ensemble of particles of the body (ion, molecule, cell, tissue, etc.) [8, 9]. The term “biofield” has been accepted by the U.S. National Library of Medicine as a medical subject heading [10]. The biofield, which surrounds the human body, can be harnessed from the Universe. It has been applied on materials or living things by experts in a controlled way to make the changes [11]. Mr. Trivedi’s unique biofield energy treatment is known as The Trivedi Effect® [12]. The Trivedi Effect has been applied in various research fields including microbiology research [13], agriculture research [14, 15], and biotechnology research [16]. Thus, by observing the various transformations happened due to the unique biofield treatment of Mr. Trivedi, this study aimed to evaluate the impact of biofield energy treatment on 4-bromoacetophenone with respect to their physical, thermal and spectral properties.

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