Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing

What is it about?

While granulomas have been extensively studied, there is poor understanding about protective immunity and in tuberculosis cavities which are the major sign of disease in patients. We used advanced genetic sequencing and mathematical models to map immune responses along the tuberculosis cavity in patients and compared these to lung tissue from those without tuberculosis. Immune containment of bacterial growth was identified in the center of the cavity, and was due to several specific immune pathways, which could be manipulated to improve therapy in the future.

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