What is it about?
Inflammatory response is a very complex issue in community-acquired pneumonia (CAP). We have shown for the first time that time since onset of symptoms can affect inflammatory response in CAP. Early presenters (patients with less than 3 days of symptoms) have lower levels of C-reactive protein (CRP) whereas procalcitonin (PCT) have higher levels compared to nonearly presenters.
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Why is it important?
Our findings highlight how complex is inflammatory response in CAP and it helps us to avoid underestimating a low inflammatory response measured by CRP in the early presenters. Thus, the time since the onset of symptoms must be another variable to take into account when interpreting the inflammatory response in CAP.
Perspectives
We hope this article makes an important contribution to the current knowledge. In the future, clinical trials assessing outcomes and inflammatory response in CAP should be consider the present contribution. More than anything else, and if nothing else, we hope you find this article thought-provoking.
Rosario Menéndez
Hospital Universitario y Politécnico La Fe /Instituto de Investigación Sanitaria (IIS) La Fe
Read the Original
This page is a summary of: Initial Inflammatory Profile in Community-acquired Pneumonia Depends on Time since Onset of Symptoms, American Review of Respiratory Disease, August 2018, American Thoracic Society,
DOI: 10.1164/rccm.201709-1908oc.
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