What is it about?
An important goal of synthetic biology is to redesign the chromosomes of bacteria so that the organisms carry out tasks that benefit humans. We find that they tolerate a wide range of genetic changes that alter the ways that they express their genes.
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Why is it important?
The discovery that bacteria tolerate a wide range of gene regulatory changes provides confidence that our findings can be exploited in the design of industrially-relevant synthetic organisms.
Perspectives
Our encouraging finding that high-level regulatory rewiring is well tolerated by model bacteria is limited thus far to bacterial growth under laboratory conditions. It will be important to discover how genetically stable these modified organisms remain in industrially-relevant growth conditions.
Professor Charles J Dorman
University of Dublin Trinity College
Read the Original
This page is a summary of: Physiological robustness of model Gram-negative bacteria in response to genome rewiring, Microbial Physiology, August 2022, Karger Publishers,
DOI: 10.1159/000526651.
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