What is it about?
We have shown that miR-301a is directly targeting ESR1 mRNA resulting in lower protein levels and less active ESR signalling. Importantly higher expression of miR-301a seems to promote the estrogen-independent features of breast cancer cells and leads to an enrichment of the population of tumor-initiating or cancer-stem like cells.
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Why is it important?
It maps another molecular mechanism how estrogen positive breast cancer may became insensitive to the estrogen and thus do not respond to hormonal therapy.
Perspectives
This is just a beginning in the road to better understanding the complex interplay of miR-301a in the tumor biology.
Jaroslav Truksa
Read the Original
This page is a summary of: MiR-301a-3p Suppresses Estrogen Signaling by Directly Inhibiting ESR1 in ERα Positive Breast Cancer, Cellular Physiology and Biochemistry, January 2018, Karger Publishers,
DOI: 10.1159/000489687.
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