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Endothelin has long be thought to increase blood pressure. In mice, when genetically overexpressed, Endothelin actually lowers blood pressure! Probably because of its renal effects...
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This page is a summary of: Global Overexpression of ET-1 Decreases Blood Pressure - A Systematic Review and Meta-Analysis of ET-1 Transgenic Mice, Kidney and Blood Pressure Research, January 2016, Karger Publishers,
DOI: 10.1159/000450567.
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