What is it about?
Although the expression of ligands for NK cell-activating receptors is variable, the majority of melanoma cell lines express ligands for NKG2D and for DNAX accessory molecule-1 (DNAM-1). Antibody-mediated masking of NKG2D, NCRs, and DNAM-1 has proven that NKG2D, NCRs, and DNAM-1 frequently cooperate in the lysis of melanoma cells.
Featured Image
Why is it important?
In this work, we provide an overview of recent advances in the study of melanoma cells’ susceptibility to NK cell-mediated lysis and how multiple receptor-ligand interactions participate in melanoma cell elimination.
Read the Original
This page is a summary of: NK Cell Recognition and Killing of Melanoma Cells Is Controlled by Multiple Activating Receptor-Ligand Interactions, Journal of Innate Immunity, January 2011, Karger Publishers,
DOI: 10.1159/000328505.
You can read the full text:
Resources
Contributors
The following have contributed to this page
