What is it about?
A patient who experienced severe coughing of blood also had urinary bleeding, raising the possibility of Goodpasture's Syndrome, had biopsies of lung and kidneys and a different cause was uncovered.
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Why is it important?
Assumptions about classical or common presentations should not lead to automatic treatment pathways without proper investigation.
Perspectives
This publication arose in the 1980's when new pathological and imaging techniques were emerging. These allowed immunological as well as ultra-microscopic delineation of linear membrane thinning in both lung and kidney which were not associated with ani-basement membrane antibody abnormalities as would be the case in Goodpasture's Syndrome. We pioneered the idea that abnormalities associated with the same clinical syndrome could be part of non-Goodpasture's immunopathology within a spectrum of auto-immune disorders.
Professor Peter Anthony Frith
Flinders University
Read the Original
This page is a summary of: Glomerular Basement Membrane Thinning in a Patient with Hematuria and Hemoptysis Mimicking Goodpasture’s Syndrome, American Journal of Nephrology, January 1994, Karger Publishers,
DOI: 10.1159/000168685.
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