What is it about?
HNK-1 has been found to be expressed on uveal and cutaneous melanoma and proposed as a useful marker of the risk of metastasis. In vitro experiments using invasive melanoma cell lines demonstrated that an HNK-1 blockade reduces cell adhesion to extracellular matrix as well as their migrative and invasive ability.
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Why is it important?
HNK-1 was highly expressed in 12.9% of melanoma cell lines, and in vitro experiments using invasive melanoma cell lines demonstrated that an HNK-1 blockade reduces cell adhesion to extracellular matrix as well as their migrative and invasive ability.
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This page is a summary of: Functional Implications of HNK-1 Expression on Invasive Behaviour of Melanoma Cells, Tumor Biology, January 2008, Springer Science + Business Media,
DOI: 10.1159/000156707.
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