Therapeutic Benefits of Melatonin Against COVID-19

What is it about?

Already there have been retrospective studies for the administration of pineal hormone melatonin in the therapy for COVID-19 with other types of drugs like antivirals, but it needs to be escalated to reach larger geographical scales, and even to the vaccinated people as an adjuvant alone or in combination with other COVID-19 therapeutic medicines. The combo effects of anti-inflammation and antioxidation by melatonin provide an effective treatment for SARS-CoV-2. This pineal product disrupts all the chronological stages of the viral life cycle that includes cell entry, replication, and deleterious downstream signaling cascades. Melatonin stimulates the production of inflammatory cytokines and Th1 and intensifies both humoral and cell-mediated responses. Melatonin exhibits multiple antiviral activities through the increased humoral immunity. Melatonin significantly interrupts at each level of the virus life cycle to support the immune system of the host and squelch a harmful overreaction. The safety parameters of melatonin have been verified in many human studies. However, in order to ascertain further confirmations, we need to evaluate first of all safety and then efficacy of the pineal hormone melatonin against COVID-19. Its effects, when administered to COVID-19 patients, definitely require the rigorous clinical studies as the pandemic has recently shown its devastating effects in the year 2020-21.

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Photo by Martin Sanchez on Unsplash

Photo by Martin Sanchez on Unsplash

Why is it important?

This review highlights about prominent benefits of melatonin in the medication of the COVID-19 fatal infection inferred by the virus SARS-CoV-2.

Perspectives