What is it about?
Tinidazole prophylaxis was used on women undergoing abdominal hysterectomy. Vaginal carriage of anaerobes was assessed pre-operatively, and 3 and 7 days post-operatively. Tinidazole reduced the carriage rate from 56% pre-operatively to 10% and 30% on days 3 and 7 respectively. These results show tinidazole as a useful adjunct to imidazole therapy in prophylaxis and treatment of anaerobic infections.
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Why is it important?
The recent reports of imidazole-resistant anaerobes colonising the vaginal microbiome call for the use of other antimicrobials in prophylaxis and treatment of anaerobic infections. The reported reduction in anaerobe colonisation of the vaginal tract using tinidazole prophylaxis offers an alternative to the use of imidazole.
Perspectives
This research ignited my interest in anaerobic bacteria and their antimicrobial susceptibility. Because of the difficulty in culturing many of the anaerobic bacteria, this article appeared as one of a few in this line of research in South Africa. Since this article was published, there have been several reports of vaginal anaerobes developing resistance to imidazole. This makes this paper relevant even > 30 years later.
Emerita Professor Charlene WJ Africa
University of the Western Cape
Read the Original
This page is a summary of: Tinidazole in the Prophylaxis and Treatment of Anaerobic Infection, Chemotherapy, July 1980, Karger Publishers,
DOI: 10.1159/000237897.
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